- Nanodisc antivirals for coronavirus and influenza virus
- mRNA lipid nanoparticle for safe vaccine
- Recombinant botulinum neurotoxin
Development of chemical regulators of SNARE-driven membrane fusion, and development of Botox substitutes for cosmetic and therapeutic purposes.
Development of nanoperforators of viral envelope for antivirals (e.g., anti-influenza drugs)
Protein engineering of industrial enzymes for improved stability, solubility and activity
Recombinant protein production technologies (protein expression control, purification, refolding and protein characterization through spectroscopies)
Experience
2003-2005 Assistant Professor, Andong National University, Korea
2006-Present Professor, Sungkyunkwan University, Korea
Journal Articles
(2022)
Bifunctional hetero di-disc for broad-spectrum influenza neutralization.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE.
44,
-
(2022)
Synaptotagmin 11 scaffolds MKK7-JNK signaling process to promote stem-like molecular subtype gastric cancer oncogenesis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH.
41,
1
(2022)
Nanodisc-Mediated Conversion of Virustatic Antiviral Antibody to Disrupt Virus Envelope in Infected Cells.
SMALL METHODS.
6,
4
(2022)
Neuron-recognizable characteristics of peptides recombined using a neuronal binding domain of botulinum neurotoxin.
SCIENTIFIC REPORTS.
12,
1
(2022)
Chlorogenic Acid Isomers Isolated from Artemisia lavandulaefolia Exhibit Anti-Rosacea Effects In Vitro.
BIOMEDICINES.
10,
2
(2022)
Optimization of protein trans-splicing in an inducible plasmid display system for high-throughput screening and selection of soluble proteins.
ENZYME AND MICROBIAL TECHNOLOGY.
153,
-
(2021)
Development of End-Spliced Dimeric Nanodiscs for the Improved Virucidal Activity of a Nanoperforator.
ACS APPLIED MATERIALS INTERFACES.
13,
31
(2021)
Enhancing acid tolerance of Escherichia coli via viroporin-mediated export of protons and its application for efficient whole-cell biotransformation.
METABOLIC ENGINEERING.
67,
(2021)
Objective quantitation of focal sweating areas using a mouse sweat-assay model.
Bio-protocol.
11,
11
(2021)
Inducible plasmid display system for high-throughput selection of proteins with improved solubility.
JOURNAL OF BIOTECHNOLOGY.
329,
(2021)
Filamentous anti-influenza agents wrapping around viruses.
JOURNAL OF COLLOID AND INTERFACE SCIENCE.
583,
(2020)
Coptis chinensis Franch Directly Inhibits Proteolytic Activation of Kallikrein 5 and Cathelicidin Associated with Rosacea in Epidermal Keratinocytes.
MOLECULES.
25,
23
(2020)
Development of fluorescent Escherichia coli for a whole-cell sensor of 2 '-fucosyllactose.
SCIENTIFIC REPORTS.
10,
1
(2020)
Munc18-1 induces conformational changes of syntaxin-1 in multiple intermediates for SNARE assembly.
SCIENTIFIC REPORTS.
10,
1
(2020)
Reduction of focal sweating by lipid nanoparticle-delivered myricetin.
SCIENTIFIC REPORTS.
10,
1
(2020)
Rapid determination of carbapenem resistance by low-cost colorimetric methods: Propidium Iodide and alamar blue staining.
JOURNAL OF MICROBIOLOGY.
58,
5
(2020)
Characterization of Ginkgo biloba Leaf Flavonoids as Neuroexocytosis Regulators.
MOLECULES.
25,
8
(2020)
Plasmid Display for Stabilization of Enzymes Inside the Cell to Improve Whole-Cell Biotransformation Efficiency.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY.
7,
(2020)
Enhancing the oral bioavailability of curcumin using solid lipid nanoparticles.
FOOD CHEMISTRY.
302,
Patent/Intellectual Property
ｐＨ-반응 고밀도 리포단백질-유사 입자 결합체(pH-responsive high density lipoprotein-like particle conjugate).
10-1455909-0000.
20141022.
KOREA, REPUBLIC OF
비유전성 항생제 내성 저해제 및 이의 용도.
10-2011-0105985.
20140307.
KOREA, REPUBLIC OF
항알러지 물질을 스크리닝하는 방법.
10-2012-0088641.
20140306.
KOREA, REPUBLIC OF
알러지성 질환의 치료를 위한 식물추출물.
10-2012-0100118
.
20130828.
KOREA, REPUBLIC OF
알러지성 질환의 치료를 위한 펩타이드.
10-2012-0106099
.
20130822.
KOREA, REPUBLIC OF
알러지성 질환의 치료 및 예방을 위한 펩타이드.
10-2010-0062610.
20130731.
KOREA, REPUBLIC OF
Polyphenol compounds with modulating neurotransmitter release.
PCT/KR2008/001400.
20120911.
UNITED STATES
아미노산 태그가 신장된 ａｐｏＡ－Ｉ 단백질 및 인지질을 이용한 막 단백질의 고체 표면 고정화 방법.
10-2008-0098801.
20100416.
KOREA, REPUBLIC OF
신경전달물질 배출을 조정하는 천연물 추출물.
10-2008-0083883.
20090818.
KOREA, REPUBLIC OF
꽃 추출물을 함유하는 SNARE 복합체 형성을 억제하기 위한 조성물.
10-2009-0024386.
20090601.
KOREA, REPUBLIC OF
꽃 추출물을 함유하는 SNARE 복합체 형성을 억제하기 위한 조성물.
10-2009-0024386.
20090601.
KOREA, REPUBLIC OF
꽃 추출물을 함유하는 SNARE 복합체 형성을 억제하기 위한 조성물.
10-2007-0106592.
20090528.
KOREA, REPUBLIC OF
